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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on practical aspects of the research design, like recruitment and consent, adherence, and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and participants from various geographical areas. This type of heterogeneity which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the trial design.

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The purpose of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are usually requested by practitioners and policymakers to help inform their decisions. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. They should not, however be used to replace explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and 프라그마틱 환수율 (socialmediaentry.com) pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study that includes the recruitment, design, and delivery of the intervention and its follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.